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Short term coseasonal sublingual immunotherapy reduced the development of asthma in children with hay fever

https://doi.org/10.1136/ebn.8.2.44

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    Novembre E, Galli E, Landi F, et al. Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis. J Allergy Clin Immunol 2004;114:851–7.OpenUrlCrossRefPubMedWeb of Science

    Q In children with allergic rhinoconjunctivitis (hay fever), does short term coseasonal sublingual immunotherapy reduce the development of asthma and seasonal hay fever symptoms?

    METHODS

    Embedded ImageDesign:

    randomised controlled trial.

    Embedded ImageAllocation:

    {unconcealed}.*

    Embedded ImageBlinding:

    blinded {patients, healthcare providers, and data collectors}*.

    Embedded ImageFollow up period:

    3 years.

    Embedded ImageSetting:

    6 paediatric allergy centres in North Central Italy (Emilia, Tuscany, and Lazio).

    Embedded ImagePatients:

    113 children 4–16 years of age (mean age 8 y) with hay fever caused by grass pollen and clinical monosensitisation to grass pollen. Exclusion criteria: asthma, clinical sensitisation to other inhalant allergens, and previous immunotherapy …

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    Footnotes

    • ↵* Information provided by author.

    • For correspondence: Dr S E Burastero, San Raffaele Scientific Institute, Milano, Italy. burastero.samuelehsr.it

    • Source of funding: no external funding.