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  • Review: β agonist delivery by metered dose inhaler with a valved holding chamber (compared with a nebuliser) reduces admissions in preschool children and infants with acute asthma or wheezing

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Review: β agonist delivery by metered dose inhaler with a valved holding chamber (compared with a nebuliser) reduces admissions in preschool children and infants with acute asthma or wheezing

https://doi.org/10.1136/ebn.8.2.42

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    Castro-Rodriguez JA, Rodrigo GJ. Beta-agonists through metered-dose inhaler with valved holding chamber versus nebulizer for acute exacerbation of wheezing or asthma in children under 5 years of age: a systematic review with meta-analysis. J Pediatr 2004;145:172–7.OpenUrlCrossRefPubMedWeb of Science

    Q What is the relative efficacy of β agonists delivered by metered dose inhaler (MDI) with a valved holding chamber (VHC) or by nebuliser in infants and preschool children with acute exacerbations of wheezing or asthma?

    METHODS

    Embedded ImageData sources:

    Medline (1966–2003), EMBASE/Excerpta Medica (1980–2003), Cochrane Controlled Trials Register; and reference lists of included studies, reviews, and texts.

    Embedded ImageStudy selection and assessment:

    randomised controlled trials (RCTs) in any language that compared β agonist delivery by MDI + VHC with delivery by nebuliser in infants and children <5 years of age who presented to the emergency department (ED) or equivalent setting with acute exacerbation of wheezing or asthma. Exclusion criterion: studies of admitted patients. Methodological quality of individual studies was assessed using the 5 point Jadad scale …

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    Footnotes

    • For correspondence: Dr J A Castro-Rodriguez, Department of Pediatrics, School of Medicine, University of Chile, Santiago, Chile. jacastro17hotmail.com

    • Source of funding: no external funding.