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Elective surfactant increased median duration of mechanical ventilation in preterm infants with mild to moderate respiratory distress syndrome

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Q What is the efficacy of elective brief intubation for early single dose surfactant administration compared with administration as clinically indicated for preterm infants with mild to moderate respiratory distress syndrome (RDS) not requiring mechanical ventilation?


Embedded ImageDesign:

randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

unclear if blinded.

Embedded ImageFollow up period:

up to discharge from hospital.

Embedded ImageSetting:

5 centres in Texas, USA.

Embedded ImagePatients:

136 infants with birth weights ⩾1250 g, gestational age ⩽36 completed weeks, postnatal age 4–24 hours, FIO2⩾0.40 with or without nasal continuous positive airway pressure (CPAP), RDS (based on chest radiograph and clinical presentation), no requirement for mechanical ventilation, no previous treatment with surfactant, no known cardiac or respiratory related congenital anomalies, and no anomalies …

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  • For correspondence: Professor M B Escobedo, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

  • Source of funding: in part, Abbott Laboratories.