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Having a stroke increased the risk of developing dementia in older people

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Q In older people, does having a stroke increase the risk of developing dementia?


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nested case-control study of patients who had a stroke and 5 randomly allocated age and sex matched controls followed up for ⩽10 years. Patients and controls were identified from a stroke free and dementia free inception cohort drawn from the Framingham Study and regularly examined over a 20 year period (1982–2002).

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town of Framingham in Massachusetts, USA.

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212 patients (mean age 79 y, 61% women) who had their first stroke at <95 years of age, were free from dementia at the time, survived the stroke, and were available for evaluation 6 months after the index stroke. The controls were required to be alive, free from stroke and dementia, …

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  • For correspondence: Dr P A Wolf, Boston University School of Medicine, Boston, MA, USA.

  • Sources of funding: National Institutes of Health; National Institute of Ageing; National Institute of Neurological Disorders and Stroke; and Boston University Alzheimer’s Disease Center.