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Review: adding non-invasive positive pressure ventilation to usual care reduces treatment failure in respiratory failure

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Q In patients with respiratory failure precipitated by an acute exacerbation of chronic obstructive pulmonary disease (COPD), is non-invasive positive pressure ventilation (NPPV) plus usual care more effective than usual care alone for reducing rates of treatment failure, all cause mortality, and endotracheal intubation?


Embedded ImageData sources:

Cochrane Airways Group randomised controlled trials (RCTs) register, Medline, CINAHL, EMBASE/Excerpta Medica, and online respiratory journal databases (all up to April 2004); bibliographies of selected RCTs; and researchers in the field.

Embedded ImageStudy selection and assessment:

RCTs that compared usual care (including supplemental oxygen, antibiotics, bronchodilators, steroids, …

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  • For correspondence: Dr F S F Ram, National Collaborating Centre for Women and Children’s Health, London, UK.

  • Source of funding: no external funding.