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Treatment
Review: long term use of common medications for asthma reduces exacerbations in adults

https://doi.org/10.1136/ebn.8.1.14

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    Sin DD, Man J, Sharpe H, et al. Pharmacological management to reduce exacerbations in adults with asthma: a systematic review and meta-analysis. JAMA 2004;292:367–76.OpenUrlCrossRefPubMedWeb of Science

    Q In adults with asthma, does long term use of common pharmacological antiasthmatic agents reduce rates of exacerbations?

    METHODS

    Embedded ImageData sources:

    Medline, EMBASE/Excerpta Medica, and the Cochrane databases (all from 1980 to April 2004); bibliographies of relevant articles; and experts.

    Embedded ImageStudy selection and assessment:

    randomised controlled trials (RCTs) (published in English) that lasted ⩾3 months, evaluated common pharmacological treatments for adults (>19 y of age) with asthma, and reported relevant outcomes. Study quality was assessed using the Jadad scale.

    Embedded ImageOutcomes:

    exacerbation rates and forced expiratory volume in 1 second (FEV1).

    MAIN RESULTS

    4 categories of pharmacological medications were evaluated. Meta-analyses were done using a random effects model when significant data heterogeneity was detected. (1) Inhaled corticosteroids (ICSs) …

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    Footnotes

    • For correspondence: Dr D D Sin, James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, Canada. dsinmrl.ubc.ca

    • Source of funding: no external funding.