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Causation
Review: spontaneous or induced abortion is not associated with development of breast cancer

https://doi.org/10.1136/ebn.7.4.122

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    Beral V, Bull D, Doll R, et al; Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and abortion: collaborative reanalysis of data from 53 epidemiological studies, including 83 000 women with breast cancer from 16 countries. Lancet 2004;363:1007–16.OpenUrlCrossRefPubMedWeb of Science

    Q What is the association between spontaneous or induced abortion and the development of breast cancer?

    METHODS

    Embedded ImageData sources:

    Medline, EMBASE/Excerpta Medica, and PubMed (to 2003); review articles; and discussions with colleagues.

    Embedded ImageStudy selection and assessment:

    published or unpublished epidemiological studies that included ⩾100 women with incident invasive breast cancer in countries with liberal abortion laws; and systematically sought information on every woman’s reproductive history, specifically previous spontaneous and induced abortions.

    Embedded ImageOutcome:

    breast cancer.

    MAIN RESULTS

    53 studies (n = 83 000) met the inclusion criteria: 13 prospective cohort and record linkage studies (n = 44 000) and 40 retrospective population or hospital …

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    Footnotes

    • For correspondence: Secretariat, Collaborative Group on Hormonal Factors in Breast Cancer, Cancer Research UK Epidemiology Unit, Radcliffe Infirmary, Oxford, UK. epidemiology.unitcancer.org.uk

    • Sources of funding: Cancer Research UK and World Health Organisation.