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Severity of cognitive impairment at initial diagnosis of Alzheimer’s disease was the strongest predictor of survival

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Q What is the course of disease (specifically life expectancy) after an initial diagnosis of Alzheimer’s disease (AD) in community dwelling patients? Which variables are associated with survival?


Embedded ImageDesign:

inception cohort with mean follow up of 5.2 years (range 0.2–14 y).

Embedded ImageSetting:

a health maintenance organisation in Seattle, Washington, USA.

Embedded ImagePatients:

521 patients who were >60 years of age (65% women, 89% white) and newly diagnosed with possible or probable AD based on criteria of DSM-III-R (dementia) and National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer’s Disease and Related Disorders Association (probable or possible AD).

Embedded ImagePrognostic factors:

baseline …

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  • For correspondence: Dr E B Larson, University of Washington and the Group Health Cooperative, Seattle, WA, USA.

  • Source of funding: National Institute on Aging.