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  • Severity of cognitive impairment at initial diagnosis of Alzheimer’s disease was the strongest predictor of survival

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Prognosis
Severity of cognitive impairment at initial diagnosis of Alzheimer’s disease was the strongest predictor of survival

https://doi.org/10.1136/ebn.7.4.120

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    Larson EB, Shadlen MF, Wang L, et al. Survival after initial diagnosis of Alzheimer disease. Ann Intern Med 2004;140:501–9.OpenUrlCrossRefPubMedWeb of Science

    Q What is the course of disease (specifically life expectancy) after an initial diagnosis of Alzheimer’s disease (AD) in community dwelling patients? Which variables are associated with survival?

    METHODS

    Embedded ImageDesign:

    inception cohort with mean follow up of 5.2 years (range 0.2–14 y).

    Embedded ImageSetting:

    a health maintenance organisation in Seattle, Washington, USA.

    Embedded ImagePatients:

    521 patients who were >60 years of age (65% women, 89% white) and newly diagnosed with possible or probable AD based on criteria of DSM-III-R (dementia) and National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer’s Disease and Related Disorders Association (probable or possible AD).

    Embedded ImagePrognostic factors:

    baseline …

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    Footnotes

    • For correspondence: Dr E B Larson, University of Washington and the Group Health Cooperative, Seattle, WA, USA. larson.eghc.org

    • Source of funding: National Institute on Aging.