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Review: most selective serotonin reuptake inhibitors lead to adverse events that appear to outweigh the benefits in children

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Q Are selective serotonin reuptake inhibitors (SSRIs) safe for treating depression in children?


Embedded ImageData sources:

Medline, CINAHL, EMBASE/Excerpta Medica, and PsycINFO (to April 2003); Cochrane Library; reference lists; tables of contents; previous systematic reviews; Guideline Development Group information; and written requests to experts.

Embedded ImageStudy selection and assessment:

English language RCTs (or RCTs with English abstracts) that compared SSRIs with placebo in children (5–18 y) with depression; had adequate blinding, concealed allocation, and description of withdrawals; and were published in peer reviewed journals or reviewed in a report by the …

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  • For correspondence: Dr C J Whittington, University College London, London, UK.

  • Source of funding: no external funding.