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Review: single dose, oral paracetamol reduces moderate to severe postoperative pain

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Q Is single dose paracetamol (acetaminophen) efficacious and safe for acute postoperative pain?


Embedded ImageData sources:

Cochrane Controlled Trials Register (Cochrane Library, Issue 3, 2002), Specialised Register of the Cochrane Pain, Palliative, and Supportive Care group (November 2002), Medline (1966 to May 1996), PubMed (1996 to November 2002), EMBASE/Excerpta Medica (1980–96), Oxford Pain Relief database (1950–94), and reference lists of retrieved articles.

Embedded ImageStudy selection and assessment:

published, double blind, randomised controlled trials (RCTs) that compared single dose, oral, immediate release paracetamol with placebo for moderate to severe postoperative pain (>30 mm on visual analogue scale [VAS]) in adults and allocated ⩾10 patients to each treatment group. Exclusion criteria: …

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  • For correspondence: Ms J Barden, Pain Research Unit, University of Oxford, Oxford, UK.

  • Sources of funding: Anglia and Oxford RHA UK; NHS Research and Development Health Technology Evaluation Programmes UK; European Union Biomed 2 UK.