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Cholesterol lowering with simvastatin reduced stroke in patients with, or at risk of, vascular disease

https://doi.org/10.1136/ebn.7.3.82

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    Collins R, Armitage J, Parish S, et al. Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20536 people with cerebrovascular disease or other high-risk conditions. Lancet 2004;363:757–67.OpenUrlCrossRefPubMedWeb of Science

    Q Does cholesterol lowering with simvastatin reduce the incidence of stroke in patients with, or at high risk of, vascular disease?

    METHODS

    Embedded ImageDesign:

    randomised controlled trial (Heart Protection Study [HPS]).

    Embedded ImageAllocation:

    {concealed}*.

    Embedded ImageBlinding:

    blinded {patients, clinicians, and data monitoring committee}*.

    Embedded ImageFollow up period:

    5 years.

    Embedded ImageSetting:

    {69 hospitals in the UK}*.

    Embedded ImagePatients:

    20 536 patients (mean age 64 y, 75% men) who had non-fasting blood total cholesterol concentrations ⩾3.5 mmol/l (135 mg/dl) and a medical history of cerebrovascular disease, coronary …

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    Footnotes

    • ↵* Heart Protection Study Collaborative Group. Lancet 2002;360:7–22.OpenUrlCrossRefPubMedWeb of Science

    • For correspondence: Heart Protection Study, Radcliffe Infirmary, Oxford, UK. hpsctsu.ox.ac.uk

    • Sources of funding: UK Medical Research Council; British Heart Foundation; Merck & Co; Roche Vitamins Ltd.