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Cholesterol lowering with simvastatin reduced stroke in patients with, or at risk of, vascular disease

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Q Does cholesterol lowering with simvastatin reduce the incidence of stroke in patients with, or at high risk of, vascular disease?


Embedded ImageDesign:

randomised controlled trial (Heart Protection Study [HPS]).

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded {patients, clinicians, and data monitoring committee}*.

Embedded ImageFollow up period:

5 years.

Embedded ImageSetting:

{69 hospitals in the UK}*.

Embedded ImagePatients:

20 536 patients (mean age 64 y, 75% men) who had non-fasting blood total cholesterol concentrations ⩾3.5 mmol/l (135 mg/dl) and a medical history of cerebrovascular disease, coronary …

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  • For correspondence: Heart Protection Study, Radcliffe Infirmary, Oxford, UK.

  • Sources of funding: UK Medical Research Council; British Heart Foundation; Merck & Co; Roche Vitamins Ltd.