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Oestrogen plus progestogen did not prevent cardiovascular disease in postmenopausal women

https://doi.org/10.1136/ebn.7.2.49

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    Manson JE, Hsia J, Johnson KC, et al, for the Women’s Health Initiative Investigators. Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med 2003;349:523–34.OpenUrlCrossRefPubMedWeb of Science

    Q Does oestrogen plus progestogen reduce the risk of coronary heart disease (CHD) in postmenopausal women?

    METHODS

    Embedded ImageDesign:

    randomised placebo controlled trial.

    Embedded ImageAllocation:

    {concealed}*.

    Embedded ImageBlinding:

    blinded {patients, clinicians, data collectors, outcome assessors, and monitoring committee}*.

    Embedded ImageFollow up period:

    mean 5.6 years.

    Embedded ImageSetting:

    {40 clinical centres in the US}*.

    Embedded ImagePatients:

    16 608 postmenopausal women who were 50–79 years of age (mean age 63 y), had an intact uterus, and resided in the same geographic area for ⩾3 years.

    Embedded ImageInterventions:

    1 daily tablet of oral conjugated equine oestrogen, 0.625 mg, plus medroxyprogesterone acetate (Prempro, Wyeth Ayerst, Philadelphia, PA, USA), 2.5 mg, (n = 8506) or placebo (n = 8102).

    Embedded ImageOutcomes:

    CHD defined as acute myocardial …

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    Footnotes

    • ↵* Writing Group for the Women’s Health Initiative Investigators. JAMA 2000;288:321–33.OpenUrl

    • For correspondence: Dr J E Manson, Division of Preventive Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA. jmansonrics.bwh.harvard.edu

    • Source of funding: National Heart, Lung, and Blood Institute.

    • A modified version of this abstract appears in ACP Journal Club.