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Selective decontamination of the digestive tract reduced intensive care unit and hospital mortality in adults

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Q Does selective decontamination of the digestive tract (SDD) reduce mortality and acquisition of resistant bacteria in adult patients in the intensive care unit (ICU)?


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randomised controlled trial.

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to hospital discharge.

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an ICU at an academic medical centre in Amsterdam, The Netherlands.

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1090 patients >18 years of age (mean age 60 y, 59% men; based on n = 934), who had an expected duration of mechanical ventilation ⩾48 hours, an expected ICU stay of ⩾72 hours, or both. Exclusion criteria: previous ICU admission within 3 months, known hypersensitivity to study medication, pregnancy, perceived imminent death, and participation in another study.

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537 …

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  • * Information provided by author.

  • For correspondence: Dr E de Jonge, Department of Intensive Care, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands.

  • Source of funding: not stated.