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Selective decontamination of the digestive tract reduced intensive care unit and hospital mortality in adults

https://doi.org/10.1136/ebn.7.2.47

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    de Jonge E, Schultz MJ, Spanjaard L, et al. Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial. Lancet 2003;362:1011–6.OpenUrlCrossRefPubMedWeb of Science

    Q Does selective decontamination of the digestive tract (SDD) reduce mortality and acquisition of resistant bacteria in adult patients in the intensive care unit (ICU)?

    METHODS

    Embedded ImageDesign:

    randomised controlled trial.

    Embedded ImageAllocation:

    {concealed}*.

    Embedded ImageBlinding:

    unblinded.

    Embedded ImageFollow up period:

    to hospital discharge.

    Embedded ImageSetting:

    an ICU at an academic medical centre in Amsterdam, The Netherlands.

    Embedded ImagePatients:

    1090 patients >18 years of age (mean age 60 y, 59% men; based on n = 934), who had an expected duration of mechanical ventilation ⩾48 hours, an expected ICU stay of ⩾72 hours, or both. Exclusion criteria: previous ICU admission within 3 months, known hypersensitivity to study medication, pregnancy, perceived imminent death, and participation in another study.

    Embedded ImageIntervention:

    537 …

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    Footnotes

    • ↵* Information provided by author.

    • For correspondence: Dr E de Jonge, Department of Intensive Care, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands. e.dejongeamc.uva.nl

    • Source of funding: not stated.