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Higher oxygen saturation targets did not improve growth and neurodevelopment in extremely preterm infants

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Q Does maintenance of higher oxygen saturation (SpO2) targets (95–98%) improve growth and neurodevelopment compared with standard targets (91–94%) in extremely preterm infants dependent on supplemental oxygen?


Embedded ImageDesign:

randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded {patients, healthcare providers, data collectors, outcome assessors, monitoring committee}*.

Embedded ImageFollow up period:

corrected age (chronologic age plus number of wks of prematurity) at 12 months.

Embedded ImageSetting:

8 tertiary perinatal centres in Sydney, Australia.

Embedded ImagePatients:

358 infants (mean age 26.5 wks, 53% boys) who were born at <30 weeks gestational age and remained dependent on supplemental oxygen at 32 weeks postmenstrual age (PA). Exclusion criteria: major congenital abnormalities; major surgery or severe intracranial disorder diagnosed at …

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  • * Information provided by author.

  • For correspondence: Dr L M Askie, RN, University of Sydney, New South Wales, Australia.

  • Source of funding: National Health and Medical Research Council of Australia and Financial Markets Foundation for Children.