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Higher oxygen saturation targets did not improve growth and neurodevelopment in extremely preterm infants

https://doi.org/10.1136/ebn.7.2.41

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    Askie LM, Henderson-Smart DJ, Irwig L, et al. Oxygen-saturation targets and outcomes in extremely preterm infants. N Engl J Med 2003;349:959–67.OpenUrlCrossRefPubMedWeb of Science

    Q Does maintenance of higher oxygen saturation (SpO2) targets (95–98%) improve growth and neurodevelopment compared with standard targets (91–94%) in extremely preterm infants dependent on supplemental oxygen?

    METHODS:

    Embedded ImageDesign:

    randomised controlled trial.

    Embedded ImageAllocation:

    concealed.

    Embedded ImageBlinding:

    blinded {patients, healthcare providers, data collectors, outcome assessors, monitoring committee}*.

    Embedded ImageFollow up period:

    corrected age (chronologic age plus number of wks of prematurity) at 12 months.

    Embedded ImageSetting:

    8 tertiary perinatal centres in Sydney, Australia.

    Embedded ImagePatients:

    358 infants (mean age 26.5 wks, 53% boys) who were born at <30 weeks gestational age and remained dependent on supplemental oxygen at 32 weeks postmenstrual age (PA). Exclusion criteria: major congenital abnormalities; major surgery or severe intracranial disorder diagnosed at …

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    Footnotes

    • ↵* Information provided by author.

    • For correspondence: Dr L M Askie, RN, University of Sydney, New South Wales, Australia. lisa.askieperinatal.usyd.edu.au

    • Source of funding: National Health and Medical Research Council of Australia and Financial Markets Foundation for Children.