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Oestrogen plus progestogen increased risk of breast cancer in postmenopausal women

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Q In postmenopausal women, does oestrogen plus progestogen hormone therapy increase the risk of abnormal mammographic results and diagnosis of breast cancer?


Embedded ImageDesign:

randomised, placebo controlled trial (Women’s Health Initiative).

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded (clinicians, participants, data collectors, outcome assessors, and monitoring committee).

Embedded ImageFollow up period:

mean 5.6 years.

Embedded ImageSetting:

40 US clinical centres.

Embedded ImagePatients:

16 608 postmenopausal women who were 50–79 years of age (mean age 63 y). Exclusion criteria: previous hysterectomy, breast cancer, or probable survival <3 years.

Embedded ImageInterventions:

1 daily tablet of conjugated equine oestrogen, …

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  • A modified version of this abstract appears in ACP Journal Club.

  • For correspondence: Dr R T Chlebowski, Harbor-UCLA Research and Education Institute, Torrance, CA, USA.

  • Sources of funding: National Heart, Lung and Blood Institute and Wyeth-Ayerst Research Laboratories.