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randomised, placebo controlled trial (Women’s Health Initiative).
blinded (clinicians, participants, data collectors, outcome assessors, and monitoring committee).
Follow up period:
mean 5.6 years.
40 US clinical centres.
16 608 postmenopausal women who were 50–79 years of age (mean age 63 y). Exclusion criteria: previous hysterectomy, breast cancer, or probable survival <3 years.
1 daily tablet of conjugated equine oestrogen, …
A modified version of this abstract appears in ACP Journal Club.
For correspondence: Dr R T Chlebowski, Harbor-UCLA Research and Education Institute, Torrance, CA, USA.
Sources of funding: National Heart, Lung and Blood Institute and Wyeth-Ayerst Research Laboratories.