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Oestrogen plus progestogen increased risk of breast cancer in postmenopausal women

https://doi.org/10.1136/ebn.7.1.16

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    Chlebowski RT, Hendrix SL, Langer RD, et al. Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women’s Health Initiative Randomized Trial. JAMA 2003;289:3243–53.OpenUrlCrossRefPubMedWeb of Science

    Q In postmenopausal women, does oestrogen plus progestogen hormone therapy increase the risk of abnormal mammographic results and diagnosis of breast cancer?

    METHODS

    Embedded ImageDesign:

    randomised, placebo controlled trial (Women’s Health Initiative).

    Embedded ImageAllocation:

    concealed.

    Embedded ImageBlinding:

    blinded (clinicians, participants, data collectors, outcome assessors, and monitoring committee).

    Embedded ImageFollow up period:

    mean 5.6 years.

    Embedded ImageSetting:

    40 US clinical centres.

    Embedded ImagePatients:

    16 608 postmenopausal women who were 50–79 years of age (mean age 63 y). Exclusion criteria: previous hysterectomy, breast cancer, or probable survival <3 years.

    Embedded ImageInterventions:

    1 daily tablet of conjugated equine oestrogen, …

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    Footnotes

    • A modified version of this abstract appears in ACP Journal Club.

    • For correspondence: Dr R T Chlebowski, Harbor-UCLA Research and Education Institute, Torrance, CA, USA. rchlebowskirei.edu

    • Sources of funding: National Heart, Lung and Blood Institute and Wyeth-Ayerst Research Laboratories.