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Intentional weight loss was associated with lower mortality, whereas unintentional weight loss was associated with increased mortality

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QUESTION: Are weight change and intention to lose weight associated with all cause mortality in adults who are overweight or obese?


Prospective cohort study with 9 years of follow up (mean follow up 8 y).




6391 adults ≥35 years of age (mean age 54 y, 55% men, 87% white) with a body mass index (BMI) ≥25 kg/m2 before weight loss.

Assessment of risk factors

Weight loss intention and weight change during the previous year were assessed by self report in a supplemental survey to the 1989 National Health Interview Survey. The same survey was used to determine age, ethnicity, sex, smoking status, self rated health, hospital admissions, physician …

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  • Source of funding: no external funding.

  • For correspondence: Dr E W Gregg, Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, US Centers for Disease Control and Prevention, Atlanta, GA, USA. edg7{at}