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  • An intensive, target driven intervention reduced cardiovascular and microvascular events in patients with type 2 diabetes and microalbuminuria

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An intensive, target driven intervention reduced cardiovascular and microvascular events in patients with type 2 diabetes and microalbuminuria

https://doi.org/10.1136/ebn.6.4.110

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    Gaede P, Vedel P, Larsen N, et al.Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes.N Engl J Med2003;348:383–93OpenUrlCrossRefPubMedWeb of Science

    QUESTION: In patients with type 2 diabetes and microalbuminuria, what is the effect of a target driven, long term, intensive, multifactorial intervention compared with conventional treatment on cardiovascular and microvascular disease?

    Design

    Randomised {allocation concealed}*, blinded {data collectors and outcome assessors}*, controlled trial with mean follow up of 7.8 years (the Steno-2 Study).

    Setting

    A diabetes centre in Denmark.

    Patients

    160 patients (mean age 55 y) with persistent microalbuminuria. Follow up was 81%.

    Intervention

    80 patients were allocated to intensive treatment involving strict treatment goals with stepwise implementation of behaviour modification (diet plan, exercise, and smoking cessation) and target driven pharmacological therapy for …

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    Footnotes

    • ↵* Information provided by author.

    • Source of funding: no external funding.

    • For correspondence: Dr O Pedersen, Steno Diabetes Center, Gentofte, Denmark. oluf{at}steno.dk

    • A modified version of this abstract appears in ACP Journal Club.