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An intensive, target driven intervention reduced cardiovascular and microvascular events in patients with type 2 diabetes and microalbuminuria

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QUESTION: In patients with type 2 diabetes and microalbuminuria, what is the effect of a target driven, long term, intensive, multifactorial intervention compared with conventional treatment on cardiovascular and microvascular disease?


Randomised {allocation concealed}*, blinded {data collectors and outcome assessors}*, controlled trial with mean follow up of 7.8 years (the Steno-2 Study).


A diabetes centre in Denmark.


160 patients (mean age 55 y) with persistent microalbuminuria. Follow up was 81%.


80 patients were allocated to intensive treatment involving strict treatment goals with stepwise implementation of behaviour modification (diet plan, exercise, and smoking cessation) and target driven pharmacological therapy for …

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  • * Information provided by author.

  • Source of funding: no external funding.

  • For correspondence: Dr O Pedersen, Steno Diabetes Center, Gentofte, Denmark. oluf{at}

  • A modified version of this abstract appears in ACP Journal Club.