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A collaborative care management programme in a primary care setting was effective for older adults with late life depression

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QUESTION: Is a collaborative care management programme offered in a primary care setting effective for older adults with late life depression?


Randomised (allocation concealed), blinded (outcome assessors) controlled trial with 1 year of follow up.


18 primary care clinics from 8 healthcare organisations in 5 states in the US.


1801 patients ≥60 years of age (mean age 71 y, 65% women) who met the Diagnostic and Statistical Manual of Mental Disorders, 4thedition criteria for major depression or dysthymia or both and who were planning to use general medical care from a participating clinic. Exclusion criteria were drinking problems, bipolar disorder or psychosis, severe cognitive impairment, or acute risk of suicide. Follow up was 98%.


906 patients …

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  • Sources of funding: John A Hartford Foundation, Hogg Foundation, California Healthcare Foundation, and Robert Wood Johnson Foundation.

  • For correspondence: Dr J Unützer, Center for Health Services Research, UCLA Neuropsychiatric Institute, Los Angeles, CA, USA. unutzer{at}