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Measles, mumps, and rubella vaccine was not associated with autism in children

https://doi.org/10.1136/ebn.6.3.89

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    Madsen KM, Hviid A, Vestergaard M, et al.A population-based study of measles, mumps, and rubella vaccination and autism.N Engl J Med2002;347:1477–82OpenUrlCrossRefPubMedWeb of Science

    QUESTION: Is the measles, mumps, and rubella (MMR) vaccine associated with autism in children?

    Design

    Population based cohort study with data obtained by database linkage.

    Setting

    Denmark.

    Participants

    537 303 children (51% boys).

    Assessment of risk factors

    MMR vaccination status was obtained from the Danish National Board of Health (compiled by general practitioner reports). Data on birth weight, sex, gestational age, family socioeconomic status, and mother’s education were also collected.

    Main outcome measures

    Children’s autism status was obtained from the Danish Psychiatric Central Register; diagnoses of autistic disorder or another autistic spectrum disorder were assigned by specialists in child psychiatry. If a child was diagnosed with both autistic disorder and ≥1 other autistic …

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    Footnotes

    • Sources of funding: Danish National Research Foundation, National Vaccine Program Office and National Immunization Program, and National Alliance for Autism Research.

    • For correspondence: Dr K M Madsen, Danish Epidemiology Science Center, Department of Epidemiology and Social Medicine, Århus, Denmark. kmm{at}dadlnet.dk

    • A modified version of this abstract appears in Evidence-Based Medicine.