You are here

Article Text

Article menu
Download PDFPDF
Treatment
Digoxin increased risk of death in women, but not men, with heart failure

https://doi.org/10.1136/ebn.6.3.80

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Rathore SS, Wang Y, Krumholz HM.Sex-based differences in the effect of digoxin for the treatment of heart failure.N Engl J Med2002;347:1403–11OpenUrlCrossRefPubMedWeb of Science

    QUESTION: Does the effect of digoxin therapy differ in men and women with heart failure (HF) and depressed left ventricular systolic function?

    Design

    Randomised {allocation concealed}*, blinded ({participants, healthcare providers,}† and data collectors), placebo controlled trial with up to 48 months of follow up.

    Setting

    302 clinical centres in the US and Canada.

    Patients

    5281 men (median age 64 y, 87% white, 30% New York Heart Association [NYHA] class ≥III) and 1519 women (median age 66 y, 81% white, 40.6% NYHA class ≥III) who had clinically confirmed HF (ie, current or past clinical symptoms or signs or radiographic evidence of pulmonary congestion) and an ejection fraction …

    View Full Text

    Footnotes

    • ↵* The Digitalis Investigation Group. N Engl J Med 1997;336:525–33.OpenUrlCrossRefPubMedWeb of Science

    • ↵† Information provided by author.

    • Source of funding: National Heart, Lung, and Blood Institute.

    • For correspondence: no information available.