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Review: hydrolysed milk formula with dietary and environmental restrictions reduces asthma and wheeze in infants with a familial history of atopy

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QUESTION: In infants with a familial history of atopy, does dietary avoidance of cows’ milk protein prevent asthma and wheeze during the first year of life?

Data sources

Studies were identified by searching Medline (1966 to Feb 2002), CINAHL (1982 to Feb 2002), EMBASE/Excerpta Medica (1980 to Feb 2002), UK National Research Register of Trials (up to Feb 2002), the Cochrane Controlled Trials Register (1966 to Feb 2002), bibliographies of identified articles, and by contacting colleagues and experts in the field.

Study selection

Randomised controlled trials (RCTs) involving children with a familial history of atopy in ≥1 first degree relative were selected if they compared hydrolysed cows’ milk formula or soya based formula with feeding …

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Footnotes

  • For correspondence: Dr F S Ram, Department of Physiological Medicine, St George’s Hospital Medical School, London, UK. fram{at}sghms.ac.uk

  • Source of funding: no external funding.