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High frequency oscillatory ventilation was not more effective than conventional ventilation in preterm infants

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QUESTION: In preterm infants who are 23–28 weeks gestational age, does high frequency oscillatory ventilation (HFOV) reduce death and chronic lung disease when compared with conventional ventilation (CV)?


Randomised (unclear allocation concealment), unblinded, controlled trial with 8–13 weeks of follow up for the primary outcome.


25 centres: 22 in the UK and 1 each in Australia, Ireland, and Singapore.


870 infants were randomised before or just after delivery. 804 surviving infants who required endotracheal intubation from birth and ongoing intensive care were included. Exclusion criteria were transfer to another hospital for intensive care shortly after birth or major congenital abnormality. 797 infants (92%) …

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  • For correspondence: Dr S A Calvert, Department of Child Health, St George’s Hospital Medical School, London, UK. scalvert{at}

  • Source of funding: Medical Research Council, London.