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Mifepristone was more effective than the Yuzpe regimen for emergency contraception

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QUESTIONS: In women seeking emergency contraception, is low dose mifepristone more effective than the Yuzpe regimen in preventing pregnancies? Does it have fewer side effects and better patient acceptability?


Randomised (allocation concealed), unblinded, controlled trial. Women were followed up for 2 weeks after the expected next menstrual period. Women who were not pregnant were followed up until their next period.


A family planning clinic in Aberdeen, Scotland.


1000 women between 16 and 45 years of age seeking emergency contraception within 72 hours after an episode of unprotected sexual intercourse who had regular menstrual cycles (21–35 d), were certain about the dates of their last menstrual period, and …

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  • For correspondence: Dr P W Ashok, Department of Obstetrics and Gynaecology, University of Aberdeen, Aberdeen Maternity Hospital, Aberdeen, UK. ashok{at}

  • Source of funding: no external funding.