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Review: pentoxifylline with standard compression treatment improves healing of venous leg ulcers

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QUESTION: Is pentoxifylline, with or without compression treatment, effective for treating venous leg ulcers?

Data sources

Published and unpublished studies in any language were identified by searching the Cochrane Wounds Group (which includes studies identified from Medline, CINAHL, and EMBASE/Excerpta Medica, and from hand searches of wound care journals and conference proceedings) and the Peripheral Vascular Disease Group trials registers (last searched May 2001); reviewing bibliographies of relevant publications; and contacting the drug manufacturer (Hoechst).

Study selection

Studies were selected if they were randomised trials comparing pentoxifylline with placebo or other treatment (with or without compression treatment) in patients with venous leg ulcers, and used an objective outcome measure of leg ulcer healing.

Data extraction

Data were extracted on study design, intervention, patients, and outcomes. Individual …

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  • Source of funding: in part, Centre for Evidence Based Nursing Aotearoa.

  • For correspondence: Mr A Jull, Clinical Trials Research Unit, University of Auckland, Auckland, New Zealand. ajull{at}

  • * Calculated from data in article