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Clinical prediction guide
A simple risk index accurately predicted mortality in patients with ST elevation myocardial infarction

https://doi.org/10.1136/ebn.5.3.90

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    Morrow DA, Antman EM, Giugliano RP, et al.A simple risk index for rapid initial triage of patients with ST-elevation myocardial infarction: an InTIME II substudy.Lancet2001 Nov 10;358:1571–5OpenUrlCrossRefPubMedWeb of Science

    QUESTION: Can a simple risk index based on 3 routinely collected variables accurately predict mortality in patients with ST elevation myocardial infarction (MI)?

    Design

    Patient data from 3 multicentre randomised controlled trials were used for the development and validation of a risk index (Intravenous nPA for the Treatment of Infarcting Myocardium Early [InTIME II] Trial; and Thrombolysis and Thrombin Inhibition in Myocardial Infarction [TIMI] 9A and B trials).

    Setting

    >800 hospitals worldwide from the InTIME II trial for index development and {150 centres in the US, UK, Canada, Israel, and Germany}* from the TIMI 9A and B trials for index validation.

    Patients

    The development set comprised data from 13 253 patients who had ST elevation MI and were enrolled within 6 hours of symptom onset, and who did not have a history of cerebrovascular disease, systolic blood pressure (SBP) …

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    Footnotes

    • Source of funding: Bristol Myers Squibb sponsored the InTIME II trial.

    • For correspondence: Dr D A Morrow, Brigham and Women's Hospital, Boston, MA, USA. damorrow{at}bics.bwh.harvard.edu