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Enteral nutrition reduced postoperative complications but increased minor adverse effects in gastrointestinal cancer

https://doi.org/10.1136/ebn.5.3.88

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    Bozzetti F, Braga M, Gianotti L, et al.Postoperative enteral versus parenteral nutrition in malnourished patients with gastrointestinal cancer: a randomised multicentre trial.Lancet2001 Nov 3;358:1487–92OpenUrlCrossRefPubMedWeb of Science

    QUESTION: In malnourished patients having elective surgery for gastrointestinal cancer, does enteral nutrition reduce postoperative complications when compared with parenteral nutrition?

    Design

    Randomised {allocation concealed}*, unblinded, controlled trial with follow up to discharge.

    Setting

    10 centres in Italy.

    Patients

    317 patients who were ≥18 years of age (mean age 64 y, 58% men) and had weight loss ≥10% of usual body weight in the previous 6 months, histologically confirmed gastrointestinal cancer, and major planned elective surgery. Exclusion criteria were hepatic, renal, or cardiac dysfunction; Karnofsky performance status <60; pregnancy; ongoing infection; or intestinal anastomosis of the large bowel without a diverting stoma. Follow up was complete.

    Intervention

    Patients were allocated to enteral …

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    Footnotes

    • Source of funding: Italian Society for Parenteral and Enteral Nutrition.

    • For correspondence: Dr F Bozzetti, Residenza Querce, Segrate (Milano), Italy. dottfb{at}tin.it

    • A modified version of this abstract appears in ACP Journal Club.