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Inactivated influenza vaccine is safe for children and adults with stable asthma

https://doi.org/10.1136/ebn.5.3.77

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    American Lung Association Asthma Clinical Research Centers. The safety of inactivated influenza vaccine in adults and children with asthma.N Engl J Med2001 Nov 22;345:1529–36OpenUrlCrossRefPubMedWeb of Science

    QUESTION: In children and adults with stable asthma, is the inactivated trivalent split virus influenza vaccine safe?

    Design

    Randomised (allocation concealed), blinded (clinicians and patients), placebo controlled crossover trial with follow up to 14 days after each injection.

    Setting

    19 centres in the US.

    Patients

    2032 patients who were 3–64 years of age, had stable asthma, and had been taking prescribed treatment for asthma within the preceding 12 months. Exclusion criteria included hypersensitivity to egg products or thimerosal, inability to use the peak flow meter properly, lack of a telephone, history of Guillain-Barré syndrome, influenza vaccine in the previous 6 months, and a temperature ≥38.0oC within 24 hours before enrolment. 1952 patients (96%) (mean age 30 y, …

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    Footnotes

    • Sources of funding: American Lung Associations; Baylor College of Medicine; Thalheim Family; Duke University; Ernest N Morial Asthma, Allergy, and Respiratory Disease Center; Merck Foundation; and Glaxo-SmithKline.

    • For correspondence: Dr M Castro, Washington University School of Medicine, St. Louis, MO, USA. mcastro{at}im.wustl.edu

    • A modified version of this abstract appears in ACP Journal club.