Article Text

Download PDFPDF
Chlorhexidine reduced catheter tip colonisation more than 10% povidone-iodine in critically ill neonates

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

OpenUrlAbstract/FREE Full Text

QUESTION: In critically ill neonates, does a chlorhexidine dressing reduce central venous catheter (CVC) tip colonisation and bloodstream infection (BSI) more than 10% povidone-iodine (PI)?


Randomised (allocation concealed), blinded {data analysts}*, controlled trial with follow up to {catheter removal and culture plus 48 hours}*.


6 level III neonatal intensive care units in 4 university teaching hospitals and 2 community hospitals in the US.


705 critically ill neonates (mean gestational age 31 wks, 57% boys, 63% white) who would likely require a CVC for ≥48 hours. Because of severe localised contact dermatitis from the chlorhexidine dressing in infants 22.5 to 26.5 weeks gestational age with a catheter inserted ≤8 days after birth, criteria were modified part way through the …

View Full Text


  • Sources of funding: in part, Johnson and Johnson Medical; Children's Foundation, Children's Hospital, Milwaukee, Wisconsin; National Institute of Health.

  • For correspondence: Dr J S Garland, St Joseph's Hospital, Milwaukee, WI, USA. jsgarland{at}