You are here

Article Text

Article menu
Download PDFPDF
Treatment
Chlorhexidine reduced catheter tip colonisation more than 10% povidone-iodine in critically ill neonates

https://doi.org/10.1136/ebn.5.3.73

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Garland JS, Alex CP, Mueller CD, et al.A randomized trial comparing povidone-iodine to a chlorhexidine gluconate-impregnated dressing for prevention of central venous catheter infections in neonates.Pediatrics2001 Jun;107:1431–7OpenUrlAbstract/FREE Full Text

    QUESTION: In critically ill neonates, does a chlorhexidine dressing reduce central venous catheter (CVC) tip colonisation and bloodstream infection (BSI) more than 10% povidone-iodine (PI)?

    Design

    Randomised (allocation concealed), blinded {data analysts}*, controlled trial with follow up to {catheter removal and culture plus 48 hours}*.

    Setting

    6 level III neonatal intensive care units in 4 university teaching hospitals and 2 community hospitals in the US.

    Patients

    705 critically ill neonates (mean gestational age 31 wks, 57% boys, 63% white) who would likely require a CVC for ≥48 hours. Because of severe localised contact dermatitis from the chlorhexidine dressing in infants 22.5 to 26.5 weeks gestational age with a catheter inserted ≤8 days after birth, criteria were modified part way through the …

    View Full Text

    Footnotes

    • Sources of funding: in part, Johnson and Johnson Medical; Children's Foundation, Children's Hospital, Milwaukee, Wisconsin; National Institute of Health.

    • For correspondence: Dr J S Garland, St Joseph's Hospital, Milwaukee, WI, USA. jsgarland{at}hotmail.com