You are here

Article Text

Article menu
Download PDFPDF
Treatment
Prone positioning for acute respiratory failure improved short term oxygenation but not survival

https://doi.org/10.1136/ebn.5.2.52

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Gattinoni L, Tognoni G, Pesenti A, et al, for the Prone-Supine Study Group. Effect of prone positioning on the survival of patients with acute respiratory failure.N Engl J Med2001 Aug 23;345:568–73OpenUrlCrossRefPubMedWeb of Science

    QUESTION: Does prone positioning for ≥ 6 hours each day for 10 days improve survival of patients with acute lung injury or the acute respiratory distress syndrome (ARDS)?

    Design

    Randomised (allocation concealed), unblinded, controlled trial with 6 months of follow up.

    Setting

    28 intensive care units (ICUs) in Italy and 2 in Switzerland.

    Patients

    304 patients (mean age 58 y, 68% men) who were receiving mechanical ventilation and met the following modified criteria for acute lung injury or ARDS: ratio of partial pressure of arterial oxygen (PaO2) to fraction of inspired oxygen (FiO2) ≤ 200 with a positive end expiratory pressure (PEEP) ≥ 5 cm of water, or a PaO2:FiO2 ratio ≤ 300 with a PEEP ≥ 10 cm water; radiographic evidence of …

    View Full Text

    Footnotes

    • Source of funding: partial funding by Hill-rom Italy.

    • For correspondence: Dr L Gattinoni, Istituto di Anestesia e Rianimazione, Ospedale Maggiore Policlinico-IRCCS, Milan, Italy. gattinon{at}policlinico.mi.it

    • Abstract and commentary appear in ACP Journal Club.