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A 30 mg/kg loading dose of acetaminophen was more effective than a 15 mg/kg maintenance dose in febrile children

https://doi.org/10.1136/ebn.5.2.42

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    Tréluyer JM, Tonnelier S, d'Athis P, et al. Antipyretic efficacy of an initial 30-mg/kg loading dose of acetaminophen versus a 15-mg/kg maintenance dose.Pediatrics2001 Oct;108:e73.OpenUrlAbstract/FREE Full Text

    QUESTION: In febrile children, is an initial 30 mg/kg loading dose of acetaminophen more effective in reducing fever than a 15 mg/kg maintenance dose?

    Design

    Randomised (unclear allocation concealment), blinded (unclear), controlled trial with 6 hours of follow up.

    Setting

    A hospital in Paris, France.

    Patients

    121 outpatients who were 4 months to 9 years of age (mean age 3 y), weighed 4–26 kg (mean weight 13 kg), and who had an initial rectal temperature of 39°C to 40.5°C, the cause of which was considered to be of viral or bacterial origin. Children were excluded if they had taken any temperature altering drug or antibiotics within the previous 24 hours; required antibiotic …

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    Footnotes

    • Source of funding: in part by Theraplix.

    • For correspondence: Dr J M Tréluyer, Pharmacologie Périnatale et Pédiatrique Hôpital Saint Vincent de Paul, Paris Cedex 14, France. jm.treluyer{at}svp.ap-hop-paris.fr