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QUESTION: In children with HIV infection at birth, who received differing treatment protocols, what are the clinical and immunological manifestations during the first 10 years of life?
Cohort study with a median of 5.8 years of follow up.
11 paediatric centres in 7 European countries.
170 HIV infected children who were born to mothers known to be infected with HIV at the time of delivery.
Assessment of prognostic factors
Children were categorised into 3 cohorts according to the treatment policy at the time of birth. Cohort 1 consisted of children born from 1985–8 when no recommendations for treatment existed; cohort 2 consisted of children born from 1989–94 when the treatment policy was restricted to monotherapy for symptomatic children; and cohort 3 consisted of children born from 1995–9 when the initiation of combination therapies was recommended at an early stage. Children were allocated to Centres for …
Sources of funding: Medical Research Council, UK and European Commission.
For correspondence: Professor M L Newell, Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
A modified version of this abstract appears in Evidence-Based Medicine.