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Review: pharmacological and non-pharmacological interventions improve outcomes in patients with dementia and their caregivers

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QUESTION: Do pharmacological, educational, or other non-pharmacological interventions improve outcomes in patients with dementia or their caregivers?

Data sources

Studies were identified to July 2000 by searching Medline, EMBASE/Excerpta Medica, CINAHL, Current Contents, Psychological Abstracts, PsychINFO, and the Cochrane databases using search terms including Alzheimer's disease (AD), vascular or multi-infarct dementia, dementia with associated parkinsonian disorder, progressive supranuclear palsy, frontotemporal dementia, and senile dementia. Additional search terms were question specific. Bibliographies of relevant papers were also reviewed.

Study selection

Studies were selected if they were randomised controlled trials published in any language or other types of studies published in English, and if they included >20 participants.

Data extraction

Data were extracted on study quality, participant characteristics, interventions, outcome measures, and results.

Main results

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  • Source of funding: no external funding.

  • For correspondence: Quality Standards Subcommittee, American Academy of Neurology, 1080 Montreal Avenue, St Paul, MN 55116, USA. Fax +1 651 695 2791.

  • A modified version of the abstract appears in ACP Journal Club and Evidence-Based Mental Health.