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Review: albumin administration is not associated with excess mortality in acutely ill patients

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QUESTION: Is albumin administration associated with excess mortality in acutely ill patients?

Data sources

Published and unpublished trials were identified by searching Medline, EMBASE/Excerpta Medica, the Cochrane Controlled Trials Register, and the Cochrane Medical Editors Trial Amnesty of unpublished trials; by searching Altavista, Northern Light, HotBot, and Excite search engines for relevant internet resources; by handsearching JAMA, New England Journal of Medicine, Lancet, and BMJ from January 1990 to November 2000; contacting albumin suppliers and authors of published randomised trials; and reviewing bibliographies of previous meta-analyses, review articles, and other investigations involving albumin. Studies in any language were considered.

Study selection

Studies were selected if they were randomised controlled trials comparing intravenous albumin treatment with crystalloid treatment, no purified …

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  • Sources of funding: Plasma Protein Therapeutics Association and American Red Cross.

  • For correspondence: Dr M M Wilkes, Hygeia Associates, 17988 Brewer Road, Grass Valley, CA 95949, USA. Fax +1 530 268 2301. A modified version of abstract and commentary appears in ACP Journal Club.