Article Text

Download PDFPDF
Review: glucosamine is more effective than selected non-steroidal anti-inflammatory drugs and placebo for reducing pain and more effective than placebo for improving function in patients with osteoarthritis

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

QUESTION: Is glucosamine effective for reducing pain and improving function in patients with osteoarthritis?

Data sources

Published and unpublished studies were identified by searching Medline (1966 to November 1999), the Cochrane Controlled Trials Register (to November 1999), and Current Contents (1998–9); searching bibliographies of retrieved papers; and by contacting authors and content experts.

Study selection

English language studies were included if they were single or double blind, randomised controlled trials evaluating the effectiveness or toxicity of glucosamine for osteoarthritis, evaluated ≥1 outcome measure in response to treatment, and included patients ≥18 years of age with a diagnosis of primary or secondary osteoarthritis at any site. Only studies with suitable quantitative data for pooling were included in the …

View Full Text


  • Source of funding: no external funding.

  • For correspondence: Dr T E Towheed, Medicine, Community Health and Epidemiology, Queen's University, Room 2066, Etherington Hall, Queen's University, Kingston, Ontario K7L 3N6, Canada. Fax +1 613 533 2189.