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  • Combined permethrin (PER) and trimethoprim/sulfamethoxazole (TMP/SMX) was better than PER alone but not better than TMP/SMX alone for treating head lice infestation in children

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Combined permethrin (PER) and trimethoprim/sulfamethoxazole (TMP/SMX) was better than PER alone but not better than TMP/SMX alone for treating head lice infestation in children

https://doi.org/10.1136/ebn.4.4.111

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    Hipolito RB, Mallorca FG, Zuniga-Macaraig ZO, et al. Head lice infestation: single drug versus combination therapy with one percent permethrin and trimethoprim/sulfamethoxazole.Pediatrics2001 Mar;107:E30.OpenUrlCrossRefPubMed

    QUESTION: Is combined permethrin (PER) and trimethoprim/sulfamethoxazole (TMP/SMX) better than either PER or TMP/SMX alone for treating head lice infestation (HLI)?

    Design

    Randomised (unclear allocation concealment), blinded (unclear), controlled trial with 4 weeks of follow up.

    Setting

    3 private paediatric and family practices in San Joaquin County, California, USA.

    Patients

    115 children who were 2–13 years of age (70% girls) and had HLI (confirmed by inspection of scalp and hair for the presence of adult lice and nymphal stage or eggs). Children with hypersensitivity to TMP/SMX or 1% PER, or a history of parental non-compliance or neglect were excluded. 97% of children completed follow up.

    Intervention

    For all groups, parents were instructed to wash the child's hair with regular …

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    Footnotes

    • ↵* p Values calculated from data in article.

    • Source of funding: not stated.

    • For correspondence: Dr R B Hipolito, University of California, Davis, School of Medicine, Department of Pediatrics, Section of Neonatology, TB 193, Davis, CA 95616, USA. rbhipo{at}aol.com