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  • Children's adverse reactions to subsequent peanut exposure were often more serious than symptoms experienced in initial reactions

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Prognosis
Children's adverse reactions to subsequent peanut exposure were often more serious than symptoms experienced in initial reactions

https://doi.org/10.1136/ebn.4.3.91

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    Vander Leek TK, Liu AH, Stefanski K, et al.The natural history of peanut allergy in young children and its association with serum peanut-specific IgE.J Pediatr2000 Dec;137:749–55OpenUrlCrossRefPubMedWeb of Science

    QUESTION: In young children with peanut allergy, what is the nature and rate of adverse reactions caused by accidental peanut exposure?

    Design

    Prospective cohort study with a median of 5.9 years (range 1.4–22.4 y) of follow up.

    Setting

    Boulder, Colorado, USA.

    Patients

    102 children with clinical peanut hypersensitivity diagnosed before their fourth birthday. Children were included if they had a convincing history of clinical peanut hypersensitivity, a positive double blind, placebo controlled food challenge response to peanuts, or both; and a positive skin prick test response to peanuts. 83 children (81%) (median age 2.4 y, 69% boys) were included in the analysis.

    Assessment of prognostic factors

    Severity of symptoms (non-life threatening or potentially life threatening) and organ system involvement (skin, respiratory, gastrointestinal, or other) with symptoms …

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    Footnotes

    • Source of funding: no external funding.

    • For correspondence: Dr S A Bock, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Room J211, Denver, CO 80206, USA. Fax +1 303 270 2189.