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Comprehensive follow up care reduced life threatening illnesses without increasing costs in high risk, inner city infants

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QUESTIONS: Does access to comprehensive follow up care reduce life threatening illnesses among high risk, inner city infants? Is it cost effective?


Randomised (allocation concealed), blinded (outcome assessors) controlled trial with follow up to age 1 year.


A follow up clinic in a private children's hospital in Dallas county, Texas, USA.


887 infants who either weighed <1000 g at birth or weighed between 1001 and 1500 g and received mechanical ventilation in the first 48 hours after birth. 783 infants (88%) were included in the primary analysis (mean maternal age 23 y; 54% black, 31% Hispanic). At 1 year follow up, 37 infants had unknown outcomes.


446 infants were allocated to comprehensive follow up care and 441 were allocated to routine care. Both groups were cared for …

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  • Sources of funding: Agency for Healthcare Research and Quality; North Texas Chapter of the National Foundation March of Dimes.

  • For correspondence: Dr J E Tyson, University of Texas-Houston Medical School, 6431 Fannin Street, MSB 3.228, Houston, TX 77030–1503, USA. Fax +1 713 500 0519.