Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
QUESTION: Is whey hydrolysate formula effective in the treatment of infantile colic in formula fed infants in a primary care setting?
Randomised (allocation concealed), blinded (research nurses and parents), placebo controlled trial with follow up immediately after 1 week of intervention.
Community based, well baby clinics in 6 regions of the Netherlands.
43 healthy, thriving, formula fed (≥1 formula feeding per d) infants <6 months old who cried for >3 hours/day on ≥3 days/week (average >4.5 h/d). Exclusion criteria included participation in a previous trial of hypoallergenic feeding, anaphylactic reactions to cows' milk, and non-Dutch speaking parents. 5 infants (12%) did not complete the trial but were included in the analysis. For the 38 who did complete the trial, 53% were boys and the mean weight was 4.7 kg.
After a 1 week qualification period, 23 infants were allocated to whey hydrolysate formula (Nutrilon Pepti) and 20 to standard cows' milk formula (Nutrilon Premium) for a 1 week intervention period. Every infant was provided with 2 cans of formula powder, each can con-taining 400 g. To make the taste, smell, and appearance of the 2 formulas similar, a quarter of the powder in each can of standard formula was substituted with hydrolysate powder.
Main outcome measures
The primary outcome …
Sources of funding: Praeventie Fonds; formulas provided by Nutricia.
For correspondence: Dr P L Lucassen, Akkerroosstraat 18, 5761 EX, Bakel, the Netherlands. Fax +31 492 343975.