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  • Oestrogen plus progestin increased venous thromboembolic disease in postmenopausal women with coronary artery disease

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Oestrogen plus progestin increased venous thromboembolic disease in postmenopausal women with coronary artery disease

https://doi.org/10.1136/ebn.3.4.123

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    Grady D, Wenger NK, Herrington D, et al for the Heart and Estrogen/progestin Replacement Study Research Group.Postmenopausal hormone therapy increases risk for venous thromboembolic disease. The Heart and Estrogen/progestin Replacement Study.Ann Intern Med2000 May 2;132:689–96OpenUrlPubMedWeb of Science

    QUESTION: Does oestrogen plus progestin increase the risk of venous thromboembolic events in postmenopausal women with established coronary artery disease (CAD)?

    Design

    Randomised {allocation concealed}*, blinded (investigators, patients, outcome assessors), placebo controlled trial with mean follow up of 4.1 years (Heart and Estrogen/progestin Replacement Study [HERS]).

    Setting

    20 clinical centres in the US.

    Patients

    2763 postmenopausal women <80 years of age (mean age 67 y, 89% white) with established CAD but no previous venous thromboembolism and who had not had …

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    Footnotes

    • Source of funding: Wyeth-Ayerst Laboratories.

    • For correspondence: Dr D Grady, University of California, San Francisco, 74 New Montgomery Street, Suite 600, San Francisco, CA 94105, USA. Fax +1 415 386 4044.

    • ↵* Information provided by author.