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Immune enhancing enteral nutrition reduced mortality and acquired infections in intensive care unit patients with sepsis

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QUESTION: Among patients in the intensive care unit (ICU) with sepsis, is immune enhancing enteral feeding more effective than high protein enteral feeding for reducing mortality and subsequent episodes of bacteraemia?


Randomised (unclear allocation concealment), unblinded controlled trial.


6 hospitals in Spain.


181 patients >14 years of age who were admitted to the ICU, had sepsis (positively cultured or clinically diagnosed infection), and had an Acute Physiology and Chronic Health Evaluation (APACHE) II score ≥10. Exclusion criteria were pregnancy, previous radiotherapy, previous treatment with immune enhancing enteral or parenteral nutrition, treatment with immunosuppressive drugs, AIDS, neoplasia, or metastases. Follow up was 97% (mean age 56 …

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  • Sources of funding: in part, Novartis Nutrition SA, Barcelona, Spain and Novartis Nutrition, Bern, Switzerland.

  • For correspondence: Dr C Galbán, Unidad de Cuidados Intensivos de adultos, Complejo Hospitalario Universitario de Santiago, Hospital Clinico Universitario, Travesia de la Choupana sin, ES-15706 Santiago de Compostela, La Coruña, Spain.