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  • Immune enhancing enteral nutrition reduced mortality and acquired infections in intensive care unit patients with sepsis

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Immune enhancing enteral nutrition reduced mortality and acquired infections in intensive care unit patients with sepsis

https://doi.org/10.1136/ebn.3.4.120

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    Galbán C, Montejo JC, Mesejo A, et al.An immune-enhancing enteral diet reduces mortality rate and episodes of bacteremia in septic intensive care unit patients.Crit Care Med2000 Mar;28:643–8OpenUrlCrossRefPubMedWeb of Science

    QUESTION: Among patients in the intensive care unit (ICU) with sepsis, is immune enhancing enteral feeding more effective than high protein enteral feeding for reducing mortality and subsequent episodes of bacteraemia?

    Design

    Randomised (unclear allocation concealment), unblinded controlled trial.

    Setting

    6 hospitals in Spain.

    Patients

    181 patients >14 years of age who were admitted to the ICU, had sepsis (positively cultured or clinically diagnosed infection), and had an Acute Physiology and Chronic Health Evaluation (APACHE) II score ≥10. Exclusion criteria were pregnancy, previous radiotherapy, previous treatment with immune enhancing enteral or parenteral nutrition, treatment with immunosuppressive drugs, AIDS, neoplasia, or metastases. Follow up was 97% (mean age 56 …

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    Footnotes

    • Sources of funding: in part, Novartis Nutrition SA, Barcelona, Spain and Novartis Nutrition, Bern, Switzerland.

    • For correspondence: Dr C Galbán, Unidad de Cuidados Intensivos de adultos, Complejo Hospitalario Universitario de Santiago, Hospital Clinico Universitario, Travesia de la Choupana sin, ES-15706 Santiago de Compostela, La Coruña, Spain.