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Review: daily maintenance inhaled corticosteroidsare not effective for children with episodic viral wheeze

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QUESTION: Are inhaled corticosteroids, given episodically or daily, effective for treatment of children with viral episodic wheeze?

Data sources

Published and unpublished randomised controlled trials were identified in April 1999 by searching the Cochrane Airways Group database (which includes studies identified from searches of Medline, EMBASE/Excerpta Medica, CINAHL, and hand searches of 16 core respiratory journals and the proceedings of 3 respiratory societies) using combinations of the terms asthma, wheez* (truncated), budesonide, pulmicort, beclomethasone, becotide, fluticasone, flixotide, triamcinolone, steroid, corticosteroid, glucocorticoid, inhaled, aerosolised, nebulised, child, infan*, pediatric, paediatric, and adolescen*; bibliographies of retrieved trials; and contacting authors.

Study selection

Studies were included if they involved children aged 0–17 years with viral episodic wheeze (defined as ≥2 episodes …

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  • Source of funding: no external funding.

  • For correspondence: Dr M McKean, Department of Child Health, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Royal Infirmary PO Box 65, Leicester LE2 7LX, UK. Fax +44 (0)116 252 3282.