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Fruit and vegetable intake decreased risk of ischaemic stroke

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QUESTION: Is increased fruit and vegetable intake associated with a reduction in ischaemic stroke?


Population based cohort study of women in the Nurses' Health Study with 14 years of follow up, and men in the Health Professionals' Follow up Study with 8 years of follow up.




121 700 women in the Nurses' Health Study who were 30-55 years of age in 1976 (baseline) and 51 529 men in the Health Professionals' Follow up Study who were 40–75 years of age in 1986 (baseline). Exclusion criteria were ≥10 non-responses to dietary questions for women or ≥70 non-responses for men; implausible scores for total food intake; or previous cancer, diabetes, or cardiovascular disease. Data from 75 596 women and 38 683 men were eligible for analysis.

Assessment of risk factors

Participants completed postal questionnaires at baseline and every 2 years thereafter. Food frequency questionnaires gathered information …

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  • Sources of funding: National Institutes of Health; State of Florida Department of Citrus.

  • For correspondence: Dr K J Joshipura, Department of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA. Fax +1 617 432 0047.

  • A modified version of this abstract appears in ACP Journal Club.