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Review: penicillin V is better than placebo and equal to non-penicillins for acute maxillary sinusitis

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QUESTION: In adults with acute maxillary sinusitis, which antibiotics lead to higher clinical cure rates?

Data sources

Studies were identified by searching Medline and EMBASE/Excerpta Medica (to October 1998) with the heading sinusitis and terms for randomised controlled trials, scanning bibliographies of relevant articles, and contacting pharmaceutical companies and experts in the field.

Study selection

Studies were selected if they were randomised controlled trials (RCTs) that compared an antibiotic with placebo or another class of antibiotic in ≥30 patients who were ≥18 years of age and had a history consistent with acute maxillary sinusitis confirmed by …

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  • Source of funding: no external funding.

  • For correspondence: Dr J W Williams Jr, South Texas Veterans Health Care System, Audie Murphy Division, 7400 Merton Minter Boulevard, San Antonio, TX 78284, USA.

  • A modified version of this abstract appears in ACP Journal Club and Evidence-Based Medicine.