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QUESTION: In patients with acute bronchitis, do antibiotic drugs reduce sputum production, cough, or days off work?
English language studies were identified in Medline (1966 to April 1998) using the terms drug therapy, bronchitis, and acute disease; the reference lists of relevant articles were reviewed, and experts in the field were contacted.
Studies were selected if they were randomised controlled trials that compared antibiotics with placebo in patients who had acute bronchitis, but no history of chronic lung disease or pneumonia; treatment was given for ≥5 days; and effect sizes could be calculated from the data presented.
Data were extracted on sample size, patient age, study inclusion and exclusion criteria, antibiotic regimen, and outcome measures. The main outcome measure was days of sputum production, which was transformed into units of standard deviation for each study.
8 studies (660 patients) were included, which used either erythromycin, doxycycline, or trimethoprim/sulfamethoxazole. The overall summary effect size of antibiotic treatment was 0.21 units of standard deviation (95% CI 0.05 to 0.36), equivalent to about 1 half day less of cough and sputum production compared with placebo. Days of purulent sputum, days of cough, and days lost from work were measured in ≥4 trials and showed no difference between antibiotics and placebo (table⇓).
In patients with acute bronchitis, the use of antibiotics reduces cough and sputum production by about half a day.
Acute bronchitis is generally self limited and primarily caused by viruses. The review by Bent et al offers a timely evaluation of an intervention that is frequently discouraged by authorities but still widely practised. The finding that antibiotics result in cough and sputum resolving approximately one half day sooner than without treatment is interesting, but the risks of treatment in an otherwise healthy individual probably outweigh these small benefits. Costs of unnecessary antibiotic treatment include medication costs, associated side effects, and increased risk of future infections with resistant bacteria. The number of individuals who improved sooner is comparable to the number who would develop adverse effects from drug therapy.
Meta-analysis of studies with similar designs and methodologies provides a more accurate measure of the overall effectiveness of the intervention.1 The findings of this meta-analysis are consistent with 2 previous systematic reviews.2–3 The challenge facing clinicians is the ease of closing a brief patient consultation with an antibiotic prescription compared with the extra time to inform and educate patients.
The results of this review indicate to all advanced practice nurses with prescribing authority, as well as other nurses in primary care settings, that they should be prepared with evidence and educational materials to better inform patients about the appropriate use of antibiotics. Antibiotics do not provide a quick fix and the one half day of symptoms saved has a long term cost.
Source of funding: no external funding.
For correspondence: Dr S Bent, General Internal Medicine Section, San Francisco Veterans Affairs Medical Center 111A1, 4150 Clement Street, San Francisco, CA 94121, USA. Fax +1 415 386 4044.
A modified version of this abstract appears in Evidence-Based Medicine and ACP Journal Club.