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  • A 42 day tapering course of dexamethasone reduced duration of assisted ventilation in very low birthweight infants, but increased risk of cerebral palsy at age 1 year

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A 42 day tapering course of dexamethasone reduced duration of assisted ventilation in very low birthweight infants, but increased risk of cerebral palsy at age 1 year

https://doi.org/10.1136/ebn.3.2.41

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    Kothadia JM, O'Shea TM, Roberts D, et al.Randomized placebo-controlled trial of a 42-day tapering course of dexamethasone to reduce the duration of ventilator dependency in very low birth weight infants.Pediatrics1999 Jul;104:22–27OpenUrlAbstract/FREE Full TextO'Shea TM, Kothadia JM, Klinepeter KL, et al.Randomized placebo-controlled trial of a 42-day tapering course of dexamethasone to reduce the duration of ventilator dependency in very low birth weight infants: outcome of study participants at 1-year adjusted age.Pediatrics1999 Jul;104:15–21OpenUrlAbstract/FREE Full Text

    QUESTION: Among very low birthweight infants, does a 42 day course of dexamethasone reduce duration of assisted ventilation and affect developmental outcome at age 1 year?

    Design

    Randomised (allocation concealed*), unblinded, placebo controlled trial with follow up at age 1 year.

    Setting

    2 neonatal intensive care units (NICUs) in North Carolina, USA.

    Patients

    118 infants (53% boys, 61% white) who were 15–25 days old and had birth weight <1501 g; <10% decrease in ventilator settings for the previous 24 hours and fraction of inspired oxygen (FIO2) ≥0.3; …

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    Footnotes

    • Source of funding for study by O'Shea et al: North Carolina Department of Environment, Health, and Natural Resources.

    • For correspondence:Dr TM O'Shea, Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA. Fax +1 336 716 2525.

    • ↵* Information provided by author.