Article Text

Download PDFPDF
Review: poor quality studies suggest that vitamin B-6 is beneficial in premenstrual syndrome

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

OpenUrlAbstract/FREE Full Text

QUESTION: Is vitamin B-6 (pyridoxine) effective for relieving overall premenstrual symptoms and depressive premenstrual symptoms?

Data sources

Studies were identified by searching Medline (1966–98), EMBASE/Excerpta Medica (1988–96), PsycLIT (1974–97), CINAHL (1982–97), and the Cochrane Controlled Trials Register with the terms premenstrual syndrome, pyridoxine, PMT, LLPDD, and PMDD. Bibliographies of relevant articles were scanned, and pharmaceutical companies were contacted.

Study selection

Published and unpublished studies in any language were selected if they were randomised, double blind, placebo controlled studies for which data could be acquired. Studies involving multivitamin supplements were included if the supplement contained ≥50 mg of vitamin B-6. Authors were contacted if additional information was required.

Data extraction

Data were extracted on participants, dose and preparation of vitamin B-6, outcome measures, results, withdrawals, side effects, and quality scores. Main outcome was subjective improvement in overall premenstrual symptoms, and a secondary …

View Full Text


  • Source of funding: no external funding.

  • For correspondence: Dr K M Wyatt, Academic Department of Obstetrics and Gynaecology, North Staffordshire Hospital, Stoke on Trent ST4 6QG, UK. Fax +44 (0)1782 552472.

  • A modified version of this abstract appears in ACP Journal Club.