Article Text

Download PDFPDF
A low dose of albuterol (salbutamol) by metered dose inhaler (MDI) with a spacer was as effective as higher doses by MDI or low doses by nebuliser in children with mild acute asthma

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

OpenUrlCrossRefPubMedWeb of Science

QUESTION: In children with mild acute asthma, is albuterol (salbutamol) delivered by a metered dose inhaler (MDI) with a spacer (standard low dose or higher, weight adjusted dose) as effective as albuterol delivered by a nebuliser?


Randomised (concealed), blinded (patient and outcome assessor), controlled trial.


A hospital emergency department in Toronto, Ontario, Canada.


90 children who were 5–17 years of age (mean 9.2 y, mean baseline forced expiratory volume in 1 second [FEV1] 62.8%) who presented with acute asthma exacerbation between 0800 and 2200, could reliably perform pulmonary function testing, and had a baseline FEV1 of 50%–79% of the predicted value. Children were excluded if this was their first wheezing episode, they had used albuterol within 4 hours of the visit, had concurrent cardiopulmonary disease, or …

View Full Text


  • Sources of funding: Physicians' Services Incorporated; Trudell Medical; Hospital for Sick Children Foundation; Department of Pediatrics, Hospital for Sick Children.

  • For correspondence: Dr S Schuh, Emergency Department, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada. Fax +1 416 813 5043.