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  • A low dose of albuterol (salbutamol) by metered dose inhaler (MDI) with a spacer was as effective as higher doses by MDI or low doses by nebuliser in children with mild acute asthma

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A low dose of albuterol (salbutamol) by metered dose inhaler (MDI) with a spacer was as effective as higher doses by MDI or low doses by nebuliser in children with mild acute asthma

https://doi.org/10.1136/ebn.3.1.12

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    Schuh S, Johnson DW, Stephens D, et al.Comparison of albuterol delivered by a metered dose inhaler with spacer versus a nebulizer in children with mild acute asthma.J Pediatr1999 Jul;135:22–7OpenUrlCrossRefPubMedWeb of Science

    QUESTION: In children with mild acute asthma, is albuterol (salbutamol) delivered by a metered dose inhaler (MDI) with a spacer (standard low dose or higher, weight adjusted dose) as effective as albuterol delivered by a nebuliser?

    Design

    Randomised (concealed), blinded (patient and outcome assessor), controlled trial.

    Setting

    A hospital emergency department in Toronto, Ontario, Canada.

    Patients

    90 children who were 5–17 years of age (mean 9.2 y, mean baseline forced expiratory volume in 1 second [FEV1] 62.8%) who presented with acute asthma exacerbation between 0800 and 2200, could reliably perform pulmonary function testing, and had a baseline FEV1 of 50%–79% of the predicted value. Children were excluded if this was their first wheezing episode, they had used albuterol within 4 hours of the visit, had concurrent cardiopulmonary disease, or …

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    Footnotes

    • Sources of funding: Physicians' Services Incorporated; Trudell Medical; Hospital for Sick Children Foundation; Department of Pediatrics, Hospital for Sick Children.

    • For correspondence: Dr S Schuh, Emergency Department, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada. Fax +1 416 813 5043.