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Children with prolonged fever are more likely to harbour serious bacterial infections
  1. Aneesh Basheer
  1. General Medicine, Dr Moopen's Medical College, Wayanad, Kerala, India
  1. Correspondence to Professor Aneesh Basheer, General Medicine, Dr Moopen's Medical College, Wayanad, Kerala, 673577, India; basheeraneesh{at}

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Commentary on: Nijman RG, Tan CD, Hagedoorn NN, Nieboer D, Herberg JA, Balode A, von Both U, Carrol ED, Eleftheriou I, Emonts M, van der Flier M, de Groot R, Kohlmaier B, Lim E, Martinón-Torres F, Pokorn M, Strle F, Tsolia M, Yeung S, Zachariasse JM, Zavadska D, Zenz W, Levin M, Vermont CL, Moll HA, Maconochie IK; PERFORM consortium. Are children with prolonged fever at a higher risk for serious illness? A prospective observational study. Arch Dis Child 2023 Aug;108(8):632-639. doi: 10.1136/archdischild-2023-325343. Epub 2023 Apr 25.

Implications for practice and research

  • Children with fever lasting 5 or more days are likely to be suffering from a serious bacterial infection (SBI) rather than viral infection.

  • Although uncommon, presence of warning signs increases the probability of SBI, while absence of warning signs is not sensitive enough to rule out SBI.


Fever is a common problem in children. Longer duration …

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  • X @basheeraneesh

  • Funding No funding was received for this work

  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.