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Managing multimorbidity in midlife may reduce the risk of developing dementia as we age
  1. Valentina Spedale1,2,
  2. Paolo Mazzola1,3
  1. 1 School of Medicine and Surgery, Università degli Studi di Milano-Bicocca, Monza, Italy
  2. 2 Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
  3. 3 Acute Geriatrics Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
  1. Correspondence to Professor Paolo Mazzola, School of Medicine and Surgery, Universita degli Studi di Milano-Bicocca, Monza, Italy; paolo.mazzola{at}

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Commentary on: Veronese N, Koyanagi A, Dominguez LJ, et al. Multimorbidity increases the risk of dementia: a 15 year follow-up of the SHARE study. Age Ageing 2023;52(4):afad052. doi: 10.1093/ageing/afad052.

Implications for practice and research

  • Stroke, hypercholesterolaemia, diabetes, and osteoporosis are modifiable risk factors for the development of dementia.

  • People with multimorbidity should be encouraged to have regular cognitive assessments starting in middle age. Meanwhile, healthy lifestyles should be promoted from childhood.


The world population is ageing significantly, with a projected 2 billion people over the age of 65 by 2050.1 A major consequence of population ageing is the increasing prevalence of dementia, which raises significantly after age 65 and is considered a global public health priority by WHO. A further consequence of ageing is the increase in multimorbidity (coexistence of ≥2 chronic conditions), which is particularly …

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  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.