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Mental health
Non-pharmacological treatments may improve cognition in mild cognitive impairment
  1. Elyse Couch
  1. Center for Gerontology and Healthcare Research, Brown University, Providence, Rhode Island, USA
  1. Correspondence to Dr Elyse Couch, Center for Gerontology and Healthcare Research, Brown University, Providence, Rhode Island 02912, USA; elyse_couch{at}

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Commentary on: Hu M, Hu H, Shao Z, Gao Y, Zeng X, Shu X, Huang J, Shen S, Wu IXY, Xiao LD, Feng H. Effectiveness and acceptability of non-pharmacological interventions in people with mild cognitive impairment: Overview of systematic reviews and network meta-analysis. J Affect Disord 2022;311:383–90. doi: 10.1016/j.jad.2022.05.043. Epub 2022 May 18.

Implications for practice and research

  • Physical activity, cognitive training and multicomponent interventions can all improve cognition and are equally acceptable to patients with mild cognitive impairment (MCI).

  • The studies included in this review were at moderate risk of bias, more methodologically rigorous research is needed


MCI is potentially reversible.1 There are very few drug treatments available for MCI and non-pharmacological interventions can be a safe and effective alternative. However, for patients to benefit from a non-pharmacological intervention, it must be both effective and acceptable to them. While a …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.